I ran my first session of this last night for a group of 3 players who had never played a tabletop rpg and who had never read the rules to this one (i made their characters for them).

It went very well! They picked up the rules quickly and the game went smoothly.

I ran one combat in which they had stumbled upon a gun fight between two rival gangs in a dockside warehouse. Since there were no rules on how to make non-super npcs i just gave them 5 stress and ruled that guns deal 2 stress. There were nine gangbangers (5 vs 4) but they werent entirely focused against the heroes (to be fair) as they were more concered with each other.

I threw in some twists and one of the heros weaknesses, but in the end they were victorious.

All in all it was a lot of fun, and very easy to run/play.